Roberto Martinez’s first match as Belgium head coach ended in defeat and jeers from the crowd as David Silva scored twice to give Spain a 2-0 win.
Spaniard Martinez, 43, was appointed on 3 August, less than three months after being sacked by Everton.
France beat Italy 3-1 as 17-year-old goalkeeper Gianluigi Donnarumma made his debut for the Azzurri.
Greece beat the Netherlands 2-1 while European champions Portugal thrashed Gibraltar 5-0.
