The ruling National Resistance Movement has conceded defeat in the Jinja East by-election.
The Forum for Democratic Change candidate Paul Mwiru was announced winner after beating his closest opponent Nathan Igeme Nabeta.
Mwiru beat Nabeta by 1701 votes becoming the winner in the hotly contested race.
Karoro however says the party is not shaken by the loss, adding that it still maintains its numerical strength in Parliament.
5 candidates contested for the seat that fell vacant after the High Court nullified the election of former MP Nathan Nabeta.
DP’s Alex Waiswa polled 291, independent Cranmar Dhikusoka got 28, while UPC’s Osinde Richie got 16 votes.